11/23/2023 0 Comments Caesium model![]() QT prolongation in the presence of low potassium usually improves quickly when potassium is administered, but 9 out of 11 of these patients receiving the potassium treatment either did not respond as well as expected or did not respond at all. QT prolongation was the most frequently reported adverse event. Reported adverse events included QT prolongation (a dangerous abnormality that can impair the heart’s ability to maintain a normal rhythm), low potassium, seizures, potentially lethal arrhythmias, fainting, cardiac arrest (the heart stopped beating), and death. In at least 8 of these cases, health care professionals measured cesium concentrations in the bodies of cesium users and found measured quantities that were several hundred to thousand-fold higher than normal. Most reports did not identify where the cesium was obtained. The doses described in these cases ranged from 500 milligrams taken every day to 100 grams taken over eleven days. Most patients took cesium to try to treat cancer. 3,6-22 Seventeen of those reports were associated with CsCl, compared to 6 with other cesium salts like cesium carbonate. Adverse EventsįDA identified 5 reports submitted to FDA and 18 published in the medical literature describing patients who experienced adverse events from cesium. FDA identified 23 reports describing serious adverse events associated with cesium, including problems with the heart. 4 FDA reviewed all adverse events related to CsCl and other cesium salts (herein referred to as “cesium”) that were reported to FDA or that were published in medical journals through June 30, 2018. FDA intends to take action, such as issue a warning letter or pursue a seizure of product or injunction, if it encounters compounding using substances placed in this category. 1,3įDA received a request that CsCl be moved to the category of bulk drug substances (active pharmaceutical ingredients) that present significant safety risks in compounding. CsCl is associated with a lower blood level of potassium, which is a mineral that is essential to normal heart function. There have been reports of humans experiencing serious heart problems after taking CsCl. Furthermore, animal research has shown that taking CsCl can cause irregular heartbeats, also called arrhythmias. However, no CsCl products have been approved by FDA to treat cancer or other diseases. Cesium chloride (CsCl) is a mineral salt that is sometimes taken either by mouth, or by injection into the body, by cancer patients who seek alternative treatments.
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